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Vitamin K 1

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Definition: A family of phylloquinones that contains a ring of 2-methyl-1,4-naphthoquinone and an isoprenoid side chain. Members of this group of vitamin K 1 have only one double bond on the proximal isoprene unit. Rich sources of vitamin K 1 include green plants, algae, and photosynthetic bacteria. Vitamin K1 has antihemorrhagic and prothrombogenic activity.  deficiency: coordinate VITAMIN K 1 (IM) with VITAMIN K DEFICIENCY (IM)   
Pharmacological Action Antifibrinolytic Agents; Vitamins 		Other names Phytonadione; Phytomenadione; Phylloquinone; Vitamin K1; Phyllohydroquinone; Konakion; AquamephytonDrugs* : AQUAMEPHYTON; VITAMIN K1; PHYTONADIONE; MEPHYTON; KONAKION
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5'-monohydroxyphylloquinone  0   Vitamin K 1/*analogs & derivatives. Plant Cell Physiol. 2012 Jan;53(1):237-43.
2-phytyl-1,4-naphthoquinone  0   Vitamin K 1/*analogs & derivatives. Biochemistry 2006 Apr 4;45(13):4121-7
dihydrophylloquinone  0   Vitamin K 1/*analogs & derivatives. J Am Diet Assoc 1999 Sep;99(9):1072-6
2-trifluoromethyl-3-phytyl-1,4-naphthoquinone  119052-95-8   Vitamin K 1/*analogs & derivatives. Biofactors 1988;1(3):255
2-(fluoromethyl)-3-(phytyl)-1,4-naphthoquione 2,3-epoxide  122408-83-7   Vitamin K 1/*analogs & derivatives. J Med Chem 1989;32(9):2138
2-(fluoromethyl)-3-phytyl-1,4-naphthoquinone  122408-82-6   Vitamin K 1/*analogs & derivatives. J Med Chem 1989;32(9):2138
vitamin K1 chromenol  34044-00-3   Vitamin K 1/*analogs & derivatives. Arch Biochem Biophys 1987;252(2):501
2-(3,7,11,15,19,23-hexamethyl-25-(2,6,6-trimethylcyclohex-2-enyl)pentacosa-2,14,18,22-tetraenyl)-3-methyl-1,4-naphthoquinone  106611-74-9   Vitamin K 1/*analogs & derivatives Nocardia. Biochem Biophys Res Commun 1986;140(3):916
3-hydroxy-2-methyl-3-phytyl-2,3-dihydronaphthoquinone  82162-05-8   Vitamin K 1/*analogs & derivatives. Proc Natl Acad Sci USA 1985;82(9):2713
vitamin K semiquinone radical  27696-10-2 1,4-Naphthalenedione, 2-methyl-3-(3,7,11,15-tetramethyl-2-hexadecenyl)-, radical ion(1-), (R-(R*,R*-(E)))  Vitamin K 1/*analogs & derivatives. Arch Biochem Biophys 1984;230(2):389
vitamin K-1 epoxide-1,4-diol  81382-12-9 Naphth(2,3-b)oxirene-2,7-diol, 1a,2,7,7a-tetrahydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)  Vitamin K 1/*analogs & derivatives. J Nutr 1982;112(2):287
vitamin K1-hydroperoxide  15576-39-3 1,4-Naphthalenedione, 2-(3-hydroperoxy-3,7,11,15-tetramethyl-1-hexadecenyl)-3-methyl  Vitamin K 1/*analogs & derivatives. Xenobiotica 1981;11(4):267
vitamin K1 aglycone III  77179-33-0 6-Octenoic acid, 8-(1,4-dihydro-3-methyl-1,4-dioxo-2-naphthalenyl)-2,6-dimethyl-, (E)  Vitamin K 1/*analogs & derivatives. Biochem Med 1981;24(3):250
vitamin K1 aglycone II  34927-45-2   Vitamin K 1/*analogs & derivatives. Biochem Med 1981;24(3):250
vitamin K1 aglycone I  51732-61-7   Vitamin K 1/*analogs & derivatives. Biochem Med 1981;24(3):250
vitamin K1 hydroquinone  572-96-3   Vitamin K 1/*analogs & derivatives. Biochem Biophys Res Commun 1980;97(4):1487
gamma-hydroxyvitamin K  1181-23-3 1,4-Naphthalenedione, 2-(3-hydroxy-3,7,11,15-tetramethylhexadecyl)-3-methyl  Vitamin K 1/*analogs & derivatives. J Biol Chem 253(15):5259;1978
vitamin K1 oxide  25486-55-9 1a,7a-dihydro-1a-methyl-7a-(3,7,11,15-tetramethyl-2-hexadecenyl)naphth(2,3-b) oxirene-2,7-dione  Vitamin K 1/*analogs & derivatives. Biochemistry 12(9):1759;1973; Fed Proc 37(12):2599;1978; Methods Enzymol 1980;67:160; Nutr Rev 36(1):20;1978
chloro-K  1258-63-5 2-chloro-3-phytyl-1,4-naphthoquinone  Vitamin K 1/*analogs & derivatives. Mol Pharmacol 10(3):373;1974; Proc Soc Exp Biol Med 150:126;1975; Science 179(069):192;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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