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Phosphoramide Mustards

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Definition: A group of nitrogen mustard compounds which are substituted with a phosphoramide group or its derivatives. They are usually cytotoxic and used as antineoplastic agents.  nitrogen mustard cpds; alkylating antineoplastics   
Pharmacological Action Antineoplastic Agents, Alkylating
Examples Cyclophosphamide 		Other names Mustards, Phosphoramide
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
TH 302  0   *Nitroimidazoles *Phosphoramide Mustards. Blood 2010 Sep 2;116(9):1524-7
N-(2,2-dimethyl-2-(2-nitrophenyl)acetyl)-4-aminocyclophosphamide  0   *Phosphoramide Mustards. Bioorg Med Chem Lett 2008 Jul 15;18(14):4059-63
carboxyethylphosphoramide mustard  0   *Phosphoramide Mustards. AAPS PharmSci. 1999;1(3):E14
2,3-didechloroethylifosfamide  0   *Phosphoramide Mustards. J Med Chem 1999 Jul 15;42(14):2542-60
dechloroethyl phosphoramide mustard  0   *Phosphoramide Mustards. Mutat Res 1997 Nov 19;381(1):49-57
N,N'-bis(2-bromoethyl)phosphorodiamidic acid  141025-16-3   *Phosphoramide Mustards. Biochem Pharmacol 1992 Mar 3;4395):937-43
isophosphamide bromide mustard  132633-97-7   *Phosphoramide Mustards. In Vivo 1990 May-Jun;4(3):209-14
GVF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Phosphoramide Mustards Vincristine. Chung Hua Wai Ko Tsa Chih 1988;26(11):648
GHVF protocol  0   *Antineoplastic Combined Chemotherapy Protocols Fluorouracil Harringtonines Phosphoramide Mustards Vincristine. Chung Hua Wai Ko Tsa Chih 1988;26(11):648
acetaldophosphamide  113341-60-9 Phosphorodiamidic acid, N,N-bis(2-chloroethyl)-, 3,3-bis(acetyloxy)propyl ester  *Phosphoramide Mustards. Cancer Res 1988;48(2):339
glyciphosphoramide  7568-40-3   *Phosphoramide Mustards. Chung Hua Chung Liu Tsa Chih 1984;6(4):293
CAP protocol 1  0   *Antineoplastic Combined Chemotherapy Protocols Cisplatin Doxorubicin Phosphoramide Mustards. Br J Cancer 1984;50(3):317
N,N-diethylphosphoramide  89314-86-3 Phosphorodiamidic acid, N,N-diethyl-, (-)  *Phosphoramide Mustards. Toxicol Appl Pharmacol 1984;72(2):283
phosphoramide mustard  10159-53-2   *Phosphoramide Mustards. Teratology 1981;23(1):7
isophosphamide mustard  31645-39-3   *Phosphoramide Mustards.
Pharma Action Antineoplastic Agents, Alkylating 		Lancet 1980;2(8196):657
2',3'-bis(2-chloroethyl)aminophosphoryl-3'-amino-3'-deoxyadenosine  70894-64-3 Adenosine, 3'-(((bis(2-chloroethyl)amino)hydroxyphosphinyl)amino)-3'-deoxy-, intramol. 3',2'-ester, (S)  *Phosphoramide Mustards. J Med Chem 22(7):882;1979
NSC-52695  4465-94-5 N,N-bis(2-chloroethyl)-N'-3-hydroxypropyl phosphorodiamidic acid  *Phosphoramide Mustards. Recent Results in Cancer Res No. 52:1;1975
aldophosphamide  35144-64-0   *Phosphoramide Mustards. Cancer Res 1980;40(1):174; Cancer Res 34(11):2933;1974; Cancer Res 37(8):2538;1977; Cancer Treatment Rep 60(4):317;1976
Preparation F-11  1950-04-5   *Phosphoramide Mustards. Zh Ushn Nos Gorl Bolezn 31(6):1971
carboxyphosphamide  22788-18-7 2-carboxyethyl-N,N-bis(2-chloroethyl)phosphorodiamidate  *Phosphoramide Mustards. Cancer Res 32(4):658;1972; J Cancer res Clin Oncol 1980;(96(1):79

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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