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Oligomycins

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Definition: A closely related group of toxic substances elaborated by various strains of Streptomyces. They are 26-membered macrolides with lactone moieties and double bonds and inhibit various ATPases, causing uncoupling of phosphorylation from mitochondrial respiration. Used as tools in cytochemistry. Some specific oligomycins are RUTAMYCIN, peliomycin, and botrycidin (formerly venturicidin X).     
Pharmacological Action Anti-Bacterial Agents; Enzyme Inhibitors; Uncoupling Agents
Examples Rutamycin 		Other names Oligomycin
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
oligomycin G  0   *Oligomycins. J Antibiot (Tokyo) 2001 Mar;54(3):308-13
44-homooligomycin E  0   *Oligomycins. Biosci Biotechnol Biochem 1997 Feb;61(2):378-80
41-demethylhomooligomycin B  0   *Oligomycins. J Antibiot (Tokyo) 1996 Dec;49(12):1275-7
oligomycin F  152726-68-6 Oligomycin A, 31-de(2-hydroxypropyl)-31-(2-hydroxybutyl)  *Oligomycins. J Antibiot (Tokyo) 1993 Sep;46(9):1334-41
44-homooligomycin B  125616-18-4   Oligomycins Streptomyces. J Antibiot (Tokyo) 1992 Feb;45(2):171-9
44-homooligomycin A  132707-68-7   Oligomycins Streptomyces. J Antibiot (Tokyo) 1992 Feb;45(2):171-9
21-hydroxyoligomycin A  102042-09-1   *Oligomycins Hydroxyl Radical. J Gen Microbiol 1991;137(Pt 10):2331
oligomycin E  110231-34-0 Oligomycin A, 26-hydroxy-28-oxo  *Oligomycins. J Antibiot (Tokyo) 1987;40(7):1053
oligomycin B  11050-94-5   *Oligomycins Proton-Translocating ATPases/antagonists & inhibitors. J Dev Physiol 1986;8(1):67
oligomycin C  11052-72-5   *Oligomycins. Biochim Biophys Acta 1984;774(2):159
oligomycin A  579-13-5   *Oligomycins. J Bioenerg Biomembr 1978;10(3/4):89
oligomycin sensitivity-conferring protein  EC 3.6.3.14   *Adenosine Triphosphatases *Carrier Proteins *Membrane Proteins Oligomycins. Biochemistry 7:1603;1968; Biochim Biophys Acta 301(1):81;1973; Methods Enzymol 55:391;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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