Myasthenia Gravis (definition)

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Myasthenia Gravis

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Definition: A disorder of neuromuscular transmission characterized by weakness of cranial and skeletal muscles. Autoantibodies directed against acetylcholine receptors damage the motor endplate portion of the NEUROMUSCULAR JUNCTION, impairing the transmission of impulses to skeletal muscles. Clinical manifestations may include diplopia, ptosis, and weakness of facial, bulbar, respiratory, and proximal limb muscles. The disease may remain limited to the ocular muscles. THYMOMA is commonly associated with this condition. (Adams et al., Principles of Neurology, 6th ed, p1459)

"myasthenia" unqualified in foreign titles is more often MYASTHENIA GRAVIS than MUSCLE WEAKNESS but check text; congen consider MYASTHENIC SYNDROMES, CONGENITAL or specifics
See Also Thymus Hyperplasia
Examples Myasthenia Gravis, Autoimmune, Experimental; Myasthenia Gravis, Neonatal

Other names Ocular Myasthenia Gravis; Generalized Myasthenia Gravis; Myasthenia Gravis, Ocular; Myasthenia Gravis, Generalized

Substance	CAS Registry & name	Categories	Source
Congenital myasthenic syndrome with episodic apnea	0	Apnea Myasthenia Gravis.
myasthenia gravis anti-skeletal muscle antibody	0	*Autoantibodies Myasthenia Gravis.	Am J Surg Pathol 1987;11(4):272

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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