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Monobactams

More information in Books or onNLM PubMed
Definition: Monocyclic, bacterially produced or semisynthetic beta-lactam antibiotics. They lack the double ring construction of the traditional beta-lactam antibiotics and can be easily synthesized.  do not use /biosyn unless by living matter   
Examples Aztreonam 		Other names beta-Lactams, Monocyclic; Monocyclic beta-Lactams; Antibiotics, Monobactam; beta Lactams, Monocyclic; Monocyclic beta Lactams; Monobactam Antibiotics
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
MK 8712  0   *Monobactams beta-Lactamases/antagonists & inhibitors. Bioorg Med Chem Lett 2011 Jul 15;21(14):4267-70
BAL 30072  0   *Monobactams *Thiazoles. Antimicrob Agents Chemother 2010 Jun;54(6):2291-302
Syn 2190  0   *Monobactams beta-Lactamases/antagonists & inhibitors. Antimicrob Agents Chemother 1999 Aug;43(8):1895-900
Ro 48-1256  0   *Monobactams beta-Lactamases/antagonists & inhibitors. J Antimicrob Chemother 1997 Sep;40(3):335-43
BMS 180680  142654-34-0   *Monobactams. Antimicrob Agents Chemother 1997 May;41(5):1010-6
RU 44790  110012-78-7 Cyclobutanecarboxylic acid, 1-(((1-(2-amino-4-thiazolyl)-2-((2-(fluoromethyl)-4-oxo-1-(1H-tetrazol-5-yl)-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-, (2S-cis)  *Monobactams. Antimicrob Agents Chemother 1992 Aug;36(8):1756-63
7-(4-chlorophenyl)-8-phenoxy-4,5-benzo-3-aza-2-nonem  85741-29-3   *Benzodiazepinones *Monobactams. Proc West Pharmacol Soc 1992;35:191-3
benzylmonobactam  80543-46-0 1-Azetidinesulfonic acid, 2-oxo-3-((phenylacetyl)amino)-, monopotassium salt, (S)  *Monobactams. J Mol Graph 1989;7(2):87
SQ 83360  104393-00-2   *Monobactams. J Clin Pharmacol 1988;28(2):113
MM 42842  113784-28-4 D-Alaninamide, D-gamma-glutamyl-N-(3-methoxy-2-methyl-4-oxo-1-sulfo-3-azetidinyl)-, (2R-trans)  *Monobactams. J Antibiot (Tokyo) 1988;41(1):7
hydroxyethylclavam  79416-52-7   *Monobactams. Arch Microbiol 1987;4(2):315
valclavam  98359-78-5   *Monobactams. Arch Microbiol 1987;4(2):315
tigemonam  102507-71-1 Acetic acid, (((1-(2-amino-4-thiazolyl)-2-((2,2-dimethyl-4-oxo-1-(sulfooxy)-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-, (S-(Z))  *Monobactams. Antimicrob Agents Chemother 1987;31(2):219
3-amino-4-methylmonobactamic acid  80082-65-1   *Monobactams. Antibiot Med Biotekhnol 1986;31(10):748
BO 1165  89426-64-2 Cyclopropanecarboxylic acid, 1-(((1-(2-amino-4-thiazolyl)-2-((2-(fluoromethyl)-4-oxo-1-sulfo-3-azetidinyl)amino)-2-oxoethylidene)amino)oxy)-, (2R-(2alpha,3beta(Z)))  *Monobactams. J Antimicrob Chemother 1986;17(6):747
ceftazidime monobactam  80904-83-2 Propanoic acid, 2-(((1-(2-amino-4-thiazolyl)-2-oxo-2-((2-oxo-1-sulfo-3-azetidinyl)amino)ethylidene)amino)oxy)-2-methyl-, (S-(Z))  *Monobactams Ceftazidime/*analogs & derivatives. Zentralbl Bakteriol Mikrobiol Hyg (A) 1983;254(2):253
cefsulodin monobactam  86710-50-1 1-Azetidinesulfonic acid, 2-oxo-3-((phenylsulfoacetyl)amino)-, (R-(R*,S*))  *Monobactams Cefsulodin/*analogs & derivatives. Zentralbl Bakteriol Mikrobiol Hyg (A) 1983;254(2):253
cefoperazone monobactam  86702-45-6 1-Azetidinesulfonic acid, 3-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)(4-hydroxyphenyl)acetyl)amino)-2-oxo-, (S-(R*,S*))  *Monobactams Cefoperazone/*analogs & derivatives. Zentralbl Bakteriol Mikrobiol Hyg (A) 1983;254(2):253
SQ 28503  88403-17-2 SQ 28503  *Monobactams. J Antibiot (Tokyo) 1983;36(10):1252
SQ 28502  88403-16-1 SQ 28502  *Monobactams. J Antibiot (Tokyo) 1983;36(10):1252
SQ 28332  88273-26-1 D-Alaninamide, N-(2,3-dihydroxy-1-oxopropyl)glycyl-O-(aminocarbonyl)-N-methyl-L-seryl-N-(2-oxo-1-sulfo-3-azetidinyl)-, monosodium salt, (1(R),3(S))  *Monobactams. J Antibiot (Tokyo) 1983;36(10):1245
sulfazecin  77912-79-9 D-Alaninamide, D-gamma-glutamyl-N-(3-methoxy-2-oxo-1-sulfo-3-azetidinyl)-, (R)  *Monobactams. Nature 1981;289(5798):590

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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