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Metyrapone

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Definition: An inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.     
Pharmacological Action Antimetabolites; Enzyme Inhibitors 		Other names Methopyrapone; Methbipyranone; Metyrapone Novartis Brand; Metyrapone Alliance Brand; 4885, SU; SU 4885; Novartis Brand of Metyrapone; M+¬topirone; Metopirone; Metopiron; Alliance Brand of MetyraponeDrugs* : METOPIRONE
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2-methoxyphenylmetyrapone N-oxide  0   *Cyclic N-Oxides Metyrapone/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1999 Jan-Mar;24(1):23-9 0
2-hydroxyphenylmetyrapone  0   Metyrapone/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1999 Jan-Mar;24(1):23-90
2-bromophenylmetyrapone  0   Metyrapone/*analogs & derivatives. Eur J Drug Metab Pharmacokinet 1999 Jan-Mar;24(1):23-9
2-methoxyphenylmetyrapone  0   Metyrapone/*analogs & derivatives. Nucl Med Biol 1995 Nov;22(8):1067-74
NKI 42255  0   Metyrapone/*analogs & derivatives. J Steroid Biochem Mol Biol 1996 May;58(2):217-23
2-iodophenylmetyrapone  0   Metyrapone/*analogs & derivatives Iodine Radioisotopes. Nucl Med Biol 1995 Feb;22(2):257-62
2-methyl-1-phenyl-2-(3-pyridinyl)-1-propanone  87372-75-6   Metyrapone/*analogs & derivatives. J Steroid Biochem 1985;22(1):104
2-methyl-1,2-diphenyl-1-propanone  13740-70-0   Metyrapone/*analogs & derivatives. J Steroid Biochem 1985;22(1):103
2-methyl-1-(3-(6-oxopyridyl))-2-(3-pyridyl)-1-propanone  78433-82-6 2(1H)-Pyridinone, 5-(2-methyl-1-oxo-2-(3-pyridinyl)propyl)  Metyrapone/*analogs & derivatives. Drug Metab Dispos 1981;9(3):270
metyrapone N-oxide  63473-06-3 1-Propanone, 2-methyl-1,3-di-3-pyridinyl-, N-oxide  Metyrapone/*analogs & derivatives. Drug Metab Dispos 7(3):166;1979
metyrapol  17159-42-1 2-methyl-1,2-bis(3-pyridyl)-1-propanol  Metyrapone/*analogs & derivatives. FEBS Lett 26(1):193;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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