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Lyases
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Definition
: A class of enzymes that catalyze the cleavage of C-C, C-O, and C-N, and other bonds by other means than by hydrolysis or oxidation. (Enzyme Nomenclature, 1992) EC 4.
Examples
Carbon-Carbon Lyases
;
Carbon-Nitrogen Lyases
;
Carbon-Oxygen Lyases
;
Carbon-Sulfur Lyases
;
Ferrochelatase
;
Phosphorus-Oxygen Lyases
Other names
Desmolases
Substance
CAS Registry & name
Categories
Source
Drugs
*
GUN5 protein, Arabidopsis
EC 4.99.1.-
*Lyases
*Arabidopsis Proteins
Membrane Proteins
Protein Subunits.
Plant Cell 2011 Apr;23(4):1449-67
indolyl-
3-
acetaldoxime dehydratase, Sclerotinia sclerotiorum
EC 4.99.1.6
*Lyases.
Phytochemistry. 2010 Dec;71(17-18):1952-62
homocysteine alpha,gamma-
lyase
EC 4.-
*Lyases
Recombinant Proteins.
Clin Chem 2002 Sep;48(9):1560-4
glutamine -
phenylpyruvate transaminase
EC 2.6.1.64
*Transaminases
*Lyases.
J Biol Chem 1986 Nov 25;261(33):15529-37
oxd protein, Bacillus
EC 4.99.-
*Lyases
*Bacterial Proteins.
Biochemistry. 2000 Feb 1;39(4):800-9.; Biosci Biotechnol Biochem. 2001 Dec;65(12):2666-72.; Protein Expr Purif. 2003 Mar;28(1):131-9.
NblB protein, Synechococcus sp.
EC 4.4.-
*Bacterial Proteins
*Lyases.
J Bacteriol 1999 Jan;181(2):610-7
PhnI protein, Rhizobium meliloti
EC 4.99.-
*Bacterial Proteins
*Lyases
Bacterial Proteins.
J Bacteriol 1999 Jan;181(2):389-95
TftG protein, Burkholderia cepacia
EC 4.5.1.-
*Bacterial Proteins
*Lyases.
J Bacteriol 1998 Sep;180(17):4667-75
formate hydrogen lyase
EC 4.99.-
*Lyases.
Biofizika 1996 Mar-Apr;41(2):369-76
ChlH protein, Synechocystis
EC 4.99.1.-
*Bacterial Proteins
*Lyases.
J Biol Chem 1996 Jul 12;271(28):16662-7
ChlD protein, Synechocystis sp. PCC 6803
EC 4.99.1.-
*Lyases
*Bacterial Proteins.
J Biol Chem 1996 Jul 12;271(28):16662-7
MerB protein, Bacteria
EC 4.99.1.2
*Bacterial Proteins
*Lyases.
Gene 1995 Dec 1;166(1):77-82
CYT2 protein, S cerevisiae
EC 4.99.-
*Lyases
*Saccharomyces cerevisiae Proteins.
J Biol Chem 1995 Sep 29;270(39):22842-9
phycoerythrocyanin alpha-
subunit phycobiliviolin lyase protein, bacteria
EC 4.4.-
*Bacterial Proteins
*Lyases.
J Biol Chem 1995 May 26;270(21):12877-84
magnesium chelatase
EC 4.99.1-
*Lyases.
Plant Physiol 1994 Feb;104(2):639-48
2-
deoxy-
scyllo-
inosose synthase
EC 4.99.-
*Lyases.
J Antibiot (Tokyo) 1993 Dec;46(12):1916-8
PabC protein, Bacteria
134548-61-1
*Bacterial Proteins
*Lyases
4-Aminobenzoic Acid.
Eur J Biochem 1993 Jan 15;211(1-2):373-6
phycocyanin alpha-
subunit phycocyanobilin lyase
EC 4.4.-
*Lyases.
Proc Natl Acad Sci U S A 1992 Aug 1;89(15):7017-21
ethylene-
forming enzyme, Pseudomonas
EC 4.-
*Lyases.
J Gen Microbiol 1991 Oct;137(Pt 10):2281
linA protein, Pseudomonas paucimobilis
EC 4.5.1.-
*Bacterial Proteins
*Lyases.
J Bacteriol 1991;173(21):5807
haloalcohol hydrogen-
halide lyase
EC 4.5.1.-
*Lyases.
J Bacteriol 1991;173(1):124
D-
selenocystine alpha, beta-
lyase
EC 4.99.-
*Lyases.
J Bacteriol 1988;170(2):751
homocysteine desulfhydrase
EC 4.4.1.2
*Lyases.
Exp Parasitol 1987;63(2):143
carbon-
phosphorus lyase
EC 4.99.-
*Lyases.
J Bacteriol 1987;169(2):710
alkylmercury lyase
EC 4.99.1.2
*Lyases.
Biochemistry 1986;25(22):7186
dichloromethane dehalogenase
EC 4.5.-
*Lyases.
J Bacteriol 1985;162(2):676
ethylene forming enzyme
EC 4.-
*Lyases.
Biochem Biophys Res Commun 1982;105(1):271
selenocysteine lyase
EC 4.4.1.16
*Lyases.
J Biol Chem 1982;257(8):4386
carbon-
sulfur lyase
EC 4.4.-
*Lyases.
Life Sci 1981;29(23):2399
cobaltochelatase
EC 4.99.1.-
*Lyases
*Bacterial Proteins.
Enzyme 1981;26(6):288
3-
chloro-
D-
alanine dehydrochlorinase
EC 4.5.1.2
*Lyases.
Biochem Biophys Res Commun 1981;100(3):1104
cytochrome C synthetase
EC 4.4.1.17
*Lyases.
J Biol Chem 1981;256(16):8646
protein A24 lyase
EC 4.-
*Lyases.
Biochemistry 1981;20(5):1100
homocysteine cystathionine gamma-
synthase
EC 4.4.-
*Lyases.
Biochem Med 9(1):90;1974
diacetyl methyl carbinol synthetase
EC 4.-
*Lyases.
Biochim Biophys Acta 279(3):554;1972
sulphoacetaldehyde lyase
EC 4.4.1.12
*Lyases.
J Biochem(Tokyo) 76(1):229;1974; J Biochem(Tokyo) 78(2):317;1975
S-
sulfocysteine synthase
EC 4.-
*Lyases.
Arch Microbiol 109(1-2):101;1976
squalene cyclase
EC 4.-
*Lyases.
J Biol Chem 245(6):1247;1970
salicylate synthetase
EC 4.-
*Lyases.
Biochim Biophys Acta 264(1):106;1972
mucopolysaccharidase
9031-30-5 Lyase, mucopolysaccharide
*Glucuronidase
*Lyases.
Arch Oral Biol 1980;24(10-11):735; J Biol Chem 240:3724;1965; J Dent Res 1980;59(5):766; J Urol Nephrol 82(7-8):695;1976; Josai Shika Daigaku Kiyo 6(1):117;1977; Jpn J Pharmacol 26:91;1976; Praxis 68(27):892;1979
1-
aminocyclopropanecarboxylate synthase
EC 4.4.1.14 S-
adenosylmethionine methylthioadenosine-
lyase (alpha, gamma-
eliminating)
*Lyases
Lyases/antagonists & inhibitors
Arabidopsis Proteins.
Arch Biochem Biophys 198(1):280;1979
dehydrochlorinases
EC 4.5.-
*Lyases.
J Environ Sci Health B13(1):25;1978
DDT-
dehydrochlorinase
EC 4.5.1.1
*Lyases.
Comp Biochem Physiol 44(2):441;1973; Pesticides 3:425;1975
cystathionine beta-
lyase
EC 4.4.1.8
*Lyases.
gamma-
cyanoaminobutyrate synthase
EC 4.-
*Lyases.
Biochemistry 12(26):5369;1973; Int J Pept Protein Res 13(1):102;1979
beta-
cyanoalanine synthase
EC 4.4.1.9
*Lyases.
Anal Biochem 83:739;1977; Arch Biochem Biophys 190(2):553;1978; Biochimie 58(1-2):9;1976; Biokhimiia 43(9):1674;1978; Int J Biochem 1980;11(1):69; Proc Natl Acad Sci USA 72(4):1617;1975
cortisol lyase
EC 4.1.2.-
*Lyases.
Endocrinology 95(1):38;1974