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Kininogens

More information in Books or onNLM PubMed
Definition: Endogenous peptides present in most body fluids. Certain enzymes convert them to active KININS which are involved in inflammation, blood clotting, complement reactions, etc. Kininogens belong to the cystatin superfamily. They are cysteine proteinase inhibitors. HIGH-MOLECULAR-WEIGHT KININOGEN; (HMWK); is split by plasma kallikrein to produce BRADYKININ. LOW-MOLECULAR-WEIGHT KININOGEN; (LMWK); is split by tissue kallikrein to produce KALLIDIN.  cysteine proteinase inhib; /drug eff /physiol permitted   
Pharmacological Action Cysteine Proteinase Inhibitors
Examples Kininogen, High-Molecular-Weight; Kininogen, Low-Molecular-Weight 		Other names Cystatins, Kininogen; T Kininogen; Kininogen Cystatins; Thiostatin; T-Kininogen; Prokinins; Prekinins; Kininogen
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Flaujeac factor deficiency  0   *Blood Coagulation Disorders Kininogens/deficiency.
PU-D1 peptide  0   *Kininogens *Peptide Fragments. Hypertension 1997 Oct;30(4):897-904
leucyl-asparaginyl-alanyl-glutamyl-asparaginyl-asparaginyl-alanine  0   *Kininogens *Peptide Fragments. Blood 1997 Aug 15;90(4):1508-15
PU-15 protein, synthetic  0   *Kininogens *Peptide Fragments. Proc Soc Exp Biol Med 1996 Jun;212(2):128-34
alpha-thiol proteinase inhibitor  0   *Kininogens Proteinase Inhibitory Proteins, Secretory. FEBS Lett 1982;138(2):307

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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