Definition: An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It occurs in cell mitochondria. The enzyme requires Mg2+, Mn2+; it is activated by ADP, citrate, and Ca2+, and inhibited by NADH, NADPH, and ATP. The reaction is the key rate-limiting step of the citric acid (tricarboxylic) cycle. (From Dorland, 27th ed) (The NADP+ enzyme is EC 1.1.1.42.) EC 1.1.1.41.
Other names NAD Isocitrate Dehydrogenase; Isocitrate Dehydrogenase, NAD; Isocitrate Dehydrogenase I; Dehydrogenase, NAD Isocitrate; Dehydrogenase, Isocitrate; Isocitrate Dehydrogenase-I; Isocitrate Dehydrogenase (NAD+)
154591-46-5
Adenosine 5'-(trihydrogen (diphosphate)), 8-((4-bromo-2,3-dioxobutyl)thio)-, P'-5'-ester with 3-(aminocarbonyl)-1-beta-D-ribofuranosylpyridinium, inner salt