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Insulysin

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Definition: An enzyme the catalyzes the degradation of insulin, glucagon and other polypeptides. It is inhibited by bacitracin, chelating agents EDTA and 1,10-phenanthroline, and by thiol-blocking reagents such as N-ethylmaleimide, but not phosphoramidon. (Eur J Biochem 1994;223:1-5) EC 3.4.24.56.      Other names Insulinase; Proteinase, Insulin; Protease, Insulin; Insulin Degrading Enzyme; Enzyme, Insulin-Degrading; Insulin-Degrading Enzyme; Insulin Proteinase; Insulin Protease
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
AXL1 protein, S cerevisiae  EC 3.4.24.-   *Metalloendopeptidases *Saccharomyces cerevisiae Proteins Insulysin. Nature 1994 Dec 8;372(6506):567-70

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