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Glutamate-Cysteine Ligase
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Definition
: One of the enzymes active in the gamma-glutamyl cycle. It catalyzes the synthesis of gamma-glutamylcysteine from glutamate and cysteine in the presence of ATP with the formation of ADP and orthophosphate. EC 6.3.2.2.
Other names
gamma-
Glutamyl-
Cysteine Synthetase; gamma Glutamyl Cysteine Synthetase; Synthetase, gamma-
Glutamyl-
Cysteine; Synthetase, Glutamylcysteine; Ligase, Glutamate-
Cysteine; Glutamate Cysteine Ligase; Glutamylcysteine Synthetase
Substance
CAS Registry & name
Categories
Source
Drugs
*
GCLM protein, mouse
EC 6.3.2.2
*Glutamate-Cysteine Ligase
Protein Subunits.
Biochem Biophys Res Commun 2000 Dec 20;279(2):324-9
glutamate-
cysteine ligase modifier subunit, human
EC 6.3.2.2
*Glutamate-Cysteine Ligase
Protein Subunits.
J Biol Chem 2009 Nov 27;284(48):33233-41
GCLC protein, rat
EC 6.3.2.2.
*Glutamate-Cysteine Ligase.
J Cell Biochem. 2009 Aug 1;107(5):944-54
Gsh1 protein, Arabidopsis
EC 6.3.2.2
*Glutamate-Cysteine Ligase.
Proc Natl Acad Sci U S A 1994 Oct 11;91(21):10059-63
GSH1 protein, S cerevisiae
EC 6.3.2.2
*Glutamate-Cysteine Ligase
*Saccharomyces cerevisiae Proteins.