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Fumarate Hydratase

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Definition: An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the citric acid cycle enzymes. EC 4.2.1.2.      Other names Fumarase; Hydratase, Fumarate
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Fumaric aciduria  0   *Metabolism, Inborn Errors *Muscle Hypotonia *Psychomotor Disorders Fumarate Hydratase/deficiency.
diamminechloro(pyridine)platinum(I)  0   *Organoplatinum Compounds Fumarate Hydratase/antagonists & inhibitors. Drug Metabol Drug Interact 1995;12(2):105-15
chloro(1,2-cyclohexanediamine-N,N')((methylsulfinyl)benzene-S)platinum(I)  124578-26-3   *Organoplatinum Compounds Fumarate Hydratase/antagonists & inhibitors. Drug Metabol Drug Interact 1995;12(2):105-15
fumarase C  EC 4.2.1.-   *Fumarate Hydratase. Nat Struct Biol 1995 Aug;2(8):654-62
2,3-dicarboxyaziridine  57528-68-4   *Aziridines Fumarate Hydratase/antagonists & inhibitors. J Biol Chem 1985;260(11):6684

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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