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Doxepin

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Definition: A dibenzoxepin tricyclic compound. It displays a range of pharmacological actions including maintaining adrenergic innervation. Its mechanism of action is not fully understood, but it appears to block reuptake of monoaminergic neurotransmitters into presynaptic terminals. It also possesses anticholinergic activity and modulates antagonism of histamine H(1)- and H(2)-receptors.     
Pharmacological Action Antidepressive Agents, Tricyclic; Histamine Antagonists 		Other names doxepinbiomo; doxepin biomo; Stada, Doxepin; Novo Doxepin; Lindo, Doxepin; Hydrochloride, Doxepin; Doxepin ratiopharm; Doxepin neuraxpharm; Doxepin TEVA; Doxepin RPh; ApoDoxepin; Apo Doxepin; ratiopharm Brand of Doxepin Hydrochloride; neuraxpharm Brand of Doxepin Hydrochloride; esparma Brand of Doxepin Hydrochloride; doxepin-biomo; biomo Brand of Doxepin Hydrochloride; betapharm Brand of Doxepin Hydrochloride; Zonalon; Teva Brand of Doxepin HydrochlorideDrugs* : SILENOR; SINEQUAN; DOXEPIN HYDROCHLORIDE; ZONALON
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
N-methyl doxepin  0   Doxepin/*analogs & derivatives. Anesth Analg. 2004 Mar;98(3):672-6
desmethyldoxepin  1225-56-5   Doxepin/*analogs & derivatives.
Pharma Action Antidepressive Agents, Tricyclic 		Acta Pharmacol Toxicol 1980;47(4):274

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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