encyclopedia of medical concepts
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DNA, Superhelical

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Definition: Circular duplex DNA isolated from viruses, bacteria and mitochondria in supercoiled or supertwisted form. This superhelical DNA is endowed with free energy. During transcription, the magnitude of RNA initiation is proportional to the DNA superhelicity.  IM; /drug eff /ultrastruct permitted    Other names DNA, Supertwisted; DNA, Supercoiled; Supertwisted DNA; Superhelical DNA; Supercoiled DNA
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
Dia2 protein, S cerevisiae  0   *Saccharomyces cerevisiae Proteins *F-Box Proteins DNA, Superhelical. Cell 2004 Dec 29;119(7):991-1000
DNA supercoiling factor, Drosophila  0   *Calcium-Binding Proteins *Nuclear Proteins *Drosophila Proteins DNA, Superhelical. Mol Cell Biol 1998 Nov;18(11):6737-44

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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