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DNA Nucleotidylexotransferase

More information in Books or onNLM PubMed
Definition: A non-template-directed DNA polymerase normally found in vertebrate thymus and bone marrow. It catalyzes the elongation of oligo- or polydeoxynucleotide chains and is widely used as a tool in the differential diagnosis of acute leukemias in man. EC 2.7.7.31.      Other names Terminal Deoxyribonucleotidyltransferase; Terminal Addition Enzyme; Transferase, Terminal Deoxyribonucleotidyl; Transferase, Terminal Deoxynucleotidyl; Transferase, Desoxynucleotidyl; Transferase, Deoxynucleotidyl; Nucleotidylexotransferase, DNA; Enzyme, Terminal Addition; Deoxyribonucleotidyltransferase, Terminal; Deoxyribonucleotidyl Transferase, Terminal; Deoxynucleotidyl Transferase, Terminal; Antigen, Tdt; Addition Enzyme, Terminal; Terminal Deoxyribonucleotidyl Transferase; Terminal Deoxynucleotidyl Transferase; Tdt Antigen; Desoxynucleotidyltransferase; Desoxynucleotidyl Transferase; Deoxynucleotidyltransferase; Deoxynucleotidyl Transferase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
untenone A  0   *Cyclopentanes *Formates DNA Nucleotidylexotransferase/antagonists & inhibitors DNA Polymerase I/antagonists & inhibitors DNA Polymerase beta/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Apr 19;14(8):1975-7
manzamenone A  0   *Formates *Indans DNA Nucleotidylexotransferase/antagonists & inhibitors DNA Polymerase I/antagonists & inhibitors Protein Kinase C/antagonists & inhibitors DNA Polymerase beta/antagonists & inhibitors. Bioorg Med Chem Lett 2004 Apr 19;14(8):1975-7
1-(6-aminopurin-9-yl)-2-(hydroxymethyl)cyclopentane triphosphate  0   Adenosine/*analogs & derivatives DNA Nucleotidylexotransferase/antagonists & inhibitors Stereoisomerism. Bioorg Med Chem 1998 Jun;6(6):701-6

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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