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DCMP Deaminase

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Definition: An enzyme that catalyzes the hydrolytic deamination of deoxycytidylic acid to deoxyuridylic acid and ammonia. It plays an important role in the regulation of the pool of deoxynucleotides in higher organisms. The enzyme also acts on some 5-substituted deoxycytidylic acids. EC 3.5.4.12.      Other names Deoxycytidylate Deaminase; Deoxycytidylate Aminohydrolase; Monophosphate Deaminase, Deoxycytidine; Deaminase, Deoxycytidylate; Deaminase, Deoxycytidine Monophosphate; Deaminase, DCMP; Aminohydrolase, Deoxycytidylate; Deoxycytidine Monophosphate Deaminase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2'-deoxy-tetrahydro-5'-uridylic acid  32017-56-4   *Deoxyuracil Nucleotides DCMP Deaminase/antagonists & inhibitors. Arch Biochem Biophys 1994 Apr;310(1):49-53
2'-deoxytetrahydrouridine  31962-88-6   Tetrahydrouridine/*analogs & derivatives DCMP Deaminase/antagonists & inhibitors. Semin Oncol 1987;14(2 Suppl 1):262

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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