encyclopedia of medical concepts
ψ
Cystathionine gamma-Lyase
More information
in Books
or on
Definition
: A multifunctional pyridoxal phosphate enzyme. In the final step in the biosynthesis of cysteine it catalyzes the cleavage of cystathionine to yield cysteine, ammonia, and 2-ketobutyrate. EC 4.4.1.1.
/defic: consider also CYSTATHIONINE /urine (IM) + AMINO ACID METABOLISM, INBORN ERRORS (IM)
Other names
gamma-
Cystathionase; Homoserine Dehydratase; Homoserine Deaminase; Cystine Desulfhydrase; Cysteine Desulfhydrase; Cystathionase; gamma-
Lyase, Cystathionine; gamma Cystathionase; Desulfohydrolase, Cystine; Desulfhydrase, Cystine; Desulfhydrase, Cysteine; Dehydratase, Homoserine; Deaminase, Homoserine; Cystathionine gamma Lyase; Cystine Desulfohydrolase
Substance
CAS Registry & name
Categories
Source
Drugs
*
cystalysin
EC 4.4.1.-
*Cystathionine gamma-Lyase.
Infect Immun 1997 Aug;65(8):3231-8
MalY protein, E coli
140881-88-5
*Cystathionine gamma-Lyase
*Repressor Proteins
*Escherichia coli Proteins
Aspartate Aminotransferases
Maltose/metabolism.
Eur J Biochem 1993 Jan15;211(1-2):373-6
CYS3 protein, S cerevisiae
EC 4.4.1.1
*Cystathionine gamma-Lyase
*Saccharomyces cerevisiae Proteins.
Mol Cell Biol 1992 Apr;12(4):1568-77
propargylglycine
64165-64-6
*Alkynes
Glycine/*analogs & derivatives
Cystathionine gamma-Lyase/antagonists & inhibitors.
Pharma Action
Enzyme Inhibitors
Biochem Pharm 27(24):2807;1978; Biochemistry 15(14):3070;1976; Biochemistry 16(11):2485;1977; Biochemistry 17(14):2864;1978; Biochemistry 17(26):5613;1978; Biochemistry 1979;18(21):4690; J Biochem 78:57;1975; J Biol Chem 1980;255(8):3487; J Chem Soc 95(18):6124;1973