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Clavulanic Acids

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Definition: Acids, salts, and derivatives of clavulanic acid (C8H9O5N). They consist of those beta-lactam compounds that differ from penicillin in having the sulfur of the thiazolidine ring replaced by an oxygen. They have limited antibacterial action, but block bacterial beta-lactamase irreversibly, so that similar antibiotics are not broken down by the bacterial enzymes and therefore can exert their antibacterial effects.  /biosyn permitted if by living matter   
Pharmacological Action Anti-Bacterial Agents; Enzyme Inhibitors
Examples Clavulanic Acid 		Other names Acids, Clavulanic
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
(3R,5R) 3-phenyl-clavam  0   *Clavulanic Acids. Bioorg Med Chem. 2004 Jan 15;12(2):405-16
clavam  0   *Clavulanic Acids. Antimicrob Agents Chemother. 2004 Mar;48(3):930-9
9-N-isobutylaminodeoxyclavulanate  0   *Clavulanic Acids beta-Lactamases/antagonists & inhibitors. J Antibiot (Tokyo) 1997 Feb;50(2):184-5
9-O-methylclavulanate  0   *Clavulanic Acids beta-Lactamases/antagonists & inhibitors. J Antibiot (Tokyo) 1997 Feb;50(2):184-5
ticarcillin-clavulanic acid  86482-18-0   Clavulanic Acids Ticarcillin beta-Lactamases/antagonists & inhibitors.
Pharma Action Anti-Bacterial Agents ; Enzyme Inhibitors 		Curr Med Res Opin 1984;9(3):157TIMENTIN; TIMENTIN IN PLASTIC CONTAINER
3-(7-oxo-1-aza-4-oxabicyclo(3.2.0)hept-3-yl)alanine  74758-63-7 4-Oxa-1-azabicyclo(3.2.0)heptane-3-propanoic acid, alpha-amino-7-oxo-, (3S-(3alpha(R*),5alpha))  *Clavulanic Acids. J Antibiot (Tokyo) 1983;36(3):213
9-deoxyclavulanic acid  69779-62-0 4-Oxa-1-azabicyclo(3.2.0)heptane-2-carboxylic acid, 3-ethylidene-7-oxo-, (2R-(2alpha,3Z,5alpha))  *Clavulanic Acids. Biochemistry 1981;20(11):3214

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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