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Chlormethiazole

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Definition: A sedative and anticonvulsant often used in the treatment of alcohol withdrawal. Chlormethiazole has also been proposed as a neuroprotective agent. The mechanism of its therapeutic activity is not entirely clear, but it does potentiate GAMMA-AMINOBUTYRIC ACID receptors response and it may also affect glycine receptors.     
Pharmacological Action Anticonvulsants; GABA Modulators; Hypnotics and Sedatives; Neuroprotective Agents 		Other names Distraneurin; Clomethiazole
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
clomethiazole edisylate  1867-58-9   Chlormethiazole/*analogs & derivatives.
Pharma Action Hypnotics and Sedatives 		Psychiatr Pol 1982;15(4-6):337
5-acetyl-4-methylthiazole  38205-55-9 ethanone, 1-(4-methyl-5-thiazolyl)  Chlormethiazole/*analogs & derivatives. J Chromatogr 1980;182(1):55
5-(1-hydroxyethyl)-4-methylthiazole  45657-12-3 5-thiazolemethanol, alpha,4-dimethyl  Chlormethiazole/*analogs & derivatives. J Chromatogr 1980 182(1):55

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
Warning: the drugs or drug combinations referred to here may be similar or related, but are not be the same ones and may not have the same pharmacological action as other substances described on the same page or in the same row. Please refer to product monograph or to your doctor
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