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Carnitine O-Palmitoyltransferase

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Definition: An enzyme that catalyzes reversibly the conversion of palmitoyl-CoA to palmitoylcarnitine in the inner mitochondrial membrane. EC 2.3.1.21.      Other names Carnitine Palmitoyltransferase; Transferase, Palmitoylcarnitine; Palmitoyltransferase, Carnitine; Palmitoyltransferase II, Carnitine; Palmitoyltransferase I, Carnitine; O-Palmitoyltransferase, Carnitine; II, Carnitine Palmitoyltransferase; Carnitine O Palmitoyltransferase; Acyltransferase, Palmitylcarnitine; Acyltransferase I, Carnitine; Palmitylcarnitine Acyltransferase; Palmitoylcarnitine Transferase; Carnitine Palmitoyltransferase II; Carnitine Palmitoyltransferase I; Carnitine Acyltransferase I; CPT II
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
CPT1B protein, mouse  EC 2.3.1.21   *Carnitine O-Palmitoyltransferase. Biol Reprod. 2010 Dec;83(6):909-18
CPT1B protein, human  EC 2.3.1.21   *Carnitine O-Palmitoyltransferase. PLoS One. 2009;4(4) (dup#18):e5394
Carnitine palmitoyl transferase 2 deficiency  0   *Metabolism, Inborn Errors Carnitine O-Palmitoyltransferase/deficiency.
Carnitine palmitoyl transferase 1A deficiency  0   *Hypoglycemia *Lipid Metabolism, Inborn Errors Carnitine O-Palmitoyltransferase/deficiency.
C75-coenzyme A  0   *Acyl Coenzyme A Carnitine O-Palmitoyltransferase/antagonists & inhibitors. Biochemistry 2006 Apr 11;45(14):4339-50
4-trimethylammonio-3-((tetradecylcarbamoyl)amino)butyrate  0   *Quaternary Ammonium Compounds *Butyrates Carnitine O-Palmitoyltransferase/antagonists & inhibitors. J Med Chem 2003 Jan 16;46(2):303-9
6-(hexadecanamidomethyl)-4,4-dimethylmorpholin-4-ium-2-acetate  0   *Morpholines Carnitine O-Palmitoyltransferase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Nov 1;9(21):3099-102
6-(tetradecanamidomethyl)-4,4-dimethylmorpholin-4-ium-2-acetate  0   *Morpholines Carnitine O-Palmitoyltransferase/antagonists & inhibitors. Bioorg Med Chem Lett 1999 Nov 1;9(21):3099-102
2-hydroxy-3-(trimethylammonio)cyclohexanecarboxylic acid  0   *Quaternary Ammonium Compounds *Cyclohexanecarboxylic Acids Carnitine O-Palmitoyltransferase/antagonists & inhibitors. Bioorg Med Chem 1999 Aug;7(8):1505-11
etomoxir  82258-36-4   *Epoxy Compounds Carnitine O-Palmitoyltransferase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors ; Hypoglycemic Agents 		Biochem Pharmacol 1987;36(22):3917
2-(6-(4-chlorophenoxy)hexyl)oxirane-2-carboxylic acid  104699-06-1   *Epoxy Compounds Carnitine O-Palmitoyltransferase/antagonists & inhibitors. Biol Neonate 1987;51(1):31
4-hydroxyphenylglycine  938-97-6 alpha-amino-4-hydroxybenzeneacetic acid  Glycine/*analogs & derivatives Carnitine O-Palmitoyltransferase/antagonists & inhibitors.
Pharma Action Enzyme Inhibitors 		Br J Pharmacol 66(3):443P;1979; Br J Pharmacol 66(3):444P;1979; Res Commun Chem Pathol Pharmacol 26(3):459;1979

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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