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Adenylyl Imidodiphosphate

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Definition: 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid. An analog of ATP, in which the oxygen atom bridging the beta to the gamma phosphate is replaced by a nitrogen atom. It is a potent competitive inhibitor of soluble and membrane-bound mitochondrial ATPase and also inhibits ATP-dependent reactions of oxidative phosphorylation.  /biosyn /physiol permitted; DF: APPNHP    Other names gamma-Imino-ATP; Adenyl Imidodiphosphate; gamma Imino ATP; gamma Imido ATP; beta,gamma imido ATP; Mg AMP PNP; Mg 5' Adenylylimidodiphosphate; Imidodiphosphate, Adenylyl; Imidodiphosphate, Adenyl; gamma-Imido-ATP; beta,gamma-imido-ATP; AMP-PNP, Mg; Mg-5'-Adenylylimidodiphosphate; Mg AMP-PNP; Adenylylimidodiphosphate; Adenylimidodiphosphate; Adenosine 5'-(beta,gamma-Imino)triphosphate; ATP(beta,gamma-NH); AMPPNP; AMP-PNP
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
2'(3')-O-methylanthraniloyl-gamma-amido-adenosine triphosphate  0   Adenylyl Imidodiphosphate/*analogs & derivatives. Biochemistry 2007 Aug 21;46(33):9654-64
gamma-amido-adenosine triphosphate  0   Adenylyl Imidodiphosphate/*analogs & derivatives. FEBS Lett 2002 May 8;518(1-3):97-100
3'(2')-O-(N-methylanthraniloyl) beta,gamma-imidoadenosine-5'-diphosphate  0   Adenylyl Imidodiphosphate/*analogs & derivatives. Biochemistry 2000 Feb 29;39(8):2106-22
2'-deoxy-5'-adenylyl imidodiphosphate  119447-19-7   Adenylyl Imidodiphosphate/*analogs & derivatives. J Biol Chem 1985;260(23):12875
N-4-azido 2-nitrophenyl gamma-aminobutyryl-5-adenylyl imidodiphosphate  84625-58-1 5'-Adenylic acid, monoanhydride with imidodiphosphoric acid, 3'-(4-((4-azido-2-nitrophenyl)amino)butanoate)  *Azides Adenylyl Imidodiphosphate/*analogs & derivatives. Biochim Biophys Acta 1982;682(1):124
ethenoadenylyl imidodiphosphate  78368-53-3 3H-Imidazo(2,1-i)purine, 3-(5-O-(hydroxy((hydroxy(phosphonoamino)phosphinyl)oxy)phosphinyl)-beta-D-ribofuranosyl)  Adenylyl Imidodiphosphate/*analogs & derivatives. J Mol Biol 1981;146(4):539

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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