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Acetylglucosaminidase

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Definition: A beta-N-Acetylhexosaminidase that catalyzes the hydrolysis of terminal, non-reducing 2-acetamido-2-deoxy-beta-glucose residues in chitobiose and higher analogs as well as in glycoproteins. Has been used widely in structural studies on bacterial cell walls and in the study of diseases such as MUCOLIPIDOSIS and various inflammatory disorders of muscle and connective tissue.  do not confuse with BETA-N-ACETYLHEXOSAMINIDASES    Other names N-Acetyl-beta-D-glucosaminidase; beta N Acetylglucosaminidase; beta D N acetylglucosaminidase; beta D Acetamido 2 Deoxyglucosidase; N,N Diacetylchitobiase; N Acetyl beta D glucosaminidase; N Ac beta Glucosaminidase; beta-N-Acetylglucosaminidase; beta-D-N-acetylglucosaminidase; beta-D-Acetamido-2-Deoxyglucosidase; NAGase; N-Ac-beta-Glucosaminidase; N,N-Diacetylchitobiase; Chitobiase
 
SubstanceCAS Registry & nameCategoriesSourceDrugs*
5-acetamidomethyl-3-hydroxymethyl-1,6,7-trihydroxypyrrolizidine  0   *Pyrrolizidine Alkaloids Acetylglucosaminidase/antagonists & inhibitors. Bioorg Med Chem 2009 Oct 15;17(20):7248-53
Ctbs protein, mouse  EC 3.2.1.-   *Acetylglucosaminidase. Gene 2008 Jun 15;416(1-2):85-91
fdl protein, Drosophila  EC 3.2.1.52   *Acetylglucosaminidase *Drosophila Proteins. J Biol Chem 2006 Feb 24;281(8):4867-75
eng-1 protein, C elegans  EC 3.2.1.52   *Acetylglucosaminidase *Caenorhabditis elegans Proteins. Glycobiology 2002 Oct;12(10):581-7
p67 deglycosylase  EC 3.2.1.-   *Acetylglucosaminidase. Biochemistry 1994 May 31;33(21):6700-6
keratanase II  EC 3.2.1.-   *Acetylglucosaminidase. Biochemistry 1994 Apr 26;33(16):4836-46
nagstatin  126844-81-3 Imidazo(1,2-a)pyridine-3-acetic acid, 8-(acetylamino)-5,6,7,8-tetrahydro-6,7-dihydroxy-5-(hydroxymethyl)  *Pyrazoles *Pyridines Acetylglucosaminidase/antagonists & inhibitors. J Antibiot (Tokyo) 1992 Sep;45(9):1557-8
5-acetamido-3,4-piperidinediol  111749-07-6   *Piperidines Acetylglucosaminidase/antagonists & inhibitors. Carbohydr Res 1987;167:312
2-acetamido-1,5-imino-1,2,5-trideoxy-D-glucitol  105265-96-1   1-Deoxynojirimycin/*analogs & derivatives Acetylglucosaminidase/antagonists & inhibitors. Carbohydr Res 1987;164:141
alpha-N-acetyl-D-glucosaminidase  EC 3.2.1.50   *Acetylglucosaminidase. Clin Genet 1981;20(2):135
4-nitrophenyl-alpha-N-acetylglucosaminidase  EC 3.2.1.-   *Acetylglucosaminidase. J Biol Chem 1980;255(18):8398
2-acetamido-2-deoxy-D-glucono-(1,5)-lactone  19026-22-3   Acetylglucosamine/*analogs & derivatives Acetylglucosaminidase/antagonists & inhibitors. Biokhimiia 38(5):1095;1973

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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