Definition: A group of 16-member MACROLIDES which stabilize MICROTUBULES in a manner similar to PACLITAXEL. They were originally found in the myxobacterium Sorangium cellulosum, now renamed to Polyangium (MYXOCOCCALES).
ixabepilone [ BMS 247550,BMS-247550,BMS247550 ] has antineoplastic activity; epothilone B lactam analogue that induces cell cycle arrest at the G(2)-M phase