encyclopedia of medical concepts
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drotrecogin alfa activated
under Protein C
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Protein C
Definition
: A vitamin-K dependent zymogen present in the blood, which, upon activation by thrombin and thrombomodulin exerts anticoagulant properties by inactivating factors Va and VIIIa at the rate-limiting steps of thrombin formation.
Substance
CAS Registry & name
Categories
Source
Drugs
*
drotrecogin alfa activated [ Lilly brand of drotrecogin alfa activated,Xigris,rhAPC ]
recombiant human activated protein C
0
*Protein C
Recombinant Proteins
Fibrinolytic Agents
Pharma Action
Anti-Infective Agents
N Engl J Med 2001 Mar 8;344(10):699-706; N Engl J Med 2006 Oct 19;365(16):1640-1642
XIGRIS