Definition: A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
Other names Tissue-Type Plasminogen Activator; T-Plasminogen Activator; Plasminogen Activator, Tissue-Type; Alteplase; Tissue Type Plasminogen Activator; Tissue Activator D 44; T Plasminogen Activator; Plasminogen Activator, Tissue Type; Plasminogen Activator, Tissue; Lysatec rtPA; Lysatec rt PA; Hoffmann La Roche Brand of Alteplase; Alteplase Promeco Brand; Alteplase Genentech Brand; Tissue Activator D-44; Tisokinase; Promeco Brand of Alteplase; Lysatec rt-PA; Hoffmann-La Roche Brand of Alteplase; Genentech Brand of Alteplase
tenecteplase [ Boehringer Ingelheim brand of tenecteplase,Genentech brand of tenecteplase,Hoffmann-La Roche brand of tenecteplase,Metalyse,TNKase ] a triple combination mutant of alteplase developed to circumvent some of the limitations of fibrinolytic therapies
