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telithromycin

under Ketolides
More information in Books or onNLM PubMed
More on Ketolides Definition: Compounds based on ERYTHROMYCIN with the 3-cladinose replaced by a ketone. They bind the 23S part of 70S bacterial RIBOSOMES.      Other names Erythromycins, 3 Keto; 3-Keto Erythromycins; 3 Keto Erythromycins; Erythromycins, 3-Keto; 3-Keto-Erythromycins
SubstanceCAS Registry & nameCategoriesSourceDrugs*
telithromycin [ Aventis brand of telithromycin,HMR 3647,HMR-3647,HMR3647,Ketek,RU 66647,RU-66647 ]
  a ketolide; semisynthetic derivative of erythromycin with cycling of the C11-12 positions to form a carbamate ring to avoid acquired resistance to macrolides; binds 70S bacterial rRNA, specifically to 		0   *Ketolides Protein Synthesis Inhibitors RNA, Ribosomal, 23S
Pharma Action Anti-Bacterial Agents 		Diagn Microbiol Infect Dis 1997 Jan-Feb;27(1-2):7-12; The Annals of Pharmacotherapy 2002 36:452-64 KETEK

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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