Definition: A mixture of mostly avermectin H2B1a (RN 71827-03-7) with some avermectin H2B1b (RN 70209-81-3), which are macrolides from STREPTOMYCES avermitilis. It binds glutamate-gated chloride channel to cause increased permeability and hyperpolarization of nerve and muscle cells. It also interacts with other CHLORIDE CHANNELS. It is a broad spectrum antiparasitic that is active against microfilariae of ONCHOCERCA VOLVULUS but not the adult form.
Other names MK933; MK 933; Ivermectin Merck Brand; Stromectol; Merck Brand of Ivermectin; Mectizan; MK-933; Ivomec; Eqvalan
4''-epiacetylamino-4''-deoxyavermectin B1 [ 4''-epiacetylamino-4''-deoxyavermectin B1, (4''R)-isomer,AAB(1) avermectin,MK-397,eprinomectin ] structure in first source; eprinomectin is the (4''R)-isomer
