Definition: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
sargramostim [ Hoechst brand of sargramostim,Immunex brand of sargramostim,Leukine,Prokine ] a glycosylated form of recombinant GM-CSF; used to treat drug-induced agranulocytosis; amino acid sequence known
123774-72-1
Colony-stimulating factor 2 (human clone pHG25 protein moiety), 23-L-leucine
