Definition: An ADP-ribosylating polypeptide produced by CORYNEBACTERIUM DIPHTHERIAE that causes the signs and symptoms of DIPHTHERIA. It can be broken into two unequal domains: the smaller, catalytic A domain is the lethal moiety and contains MONO(ADP-RIBOSE) TRANSFERASES which transfers ADP RIBOSE to PEPTIDE ELONGATION FACTOR 2 thereby inhibiting protein synthesis; and the larger B domain that is needed for entry into cells.
/antag permitted but consider also DIPHTHERIA ANTITOXIN
Other names Corynebacterium Diphtheriae Toxin; Toxin, Corynebacterium Diphtheriae
denileukin diftitox [ DAB(389)-IL-2,DAB(389)-interleukin 2,DAB(389)IL-2,DAB389-IL-2,Ligand brand of denileukin diftitox,Ontak ] more potent, truncated form of DAB(486)-IL-2; inhibit HIV-1 RNA production in infected cells
