virion host shutoff protein (definition)

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ψ	virion host shutoff protein, Simplexvirus under Ribonucleases

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Definition: Enzymes that catalyze the hydrolysis of ester bonds within RNA. EC 3.1.-.

Other names RNase; Nucleases, RNA; Ribonuclease, Alkaline; Ribonuclease, Acid; RNA Nucleases; Ribonuclease; Alkaline Ribonuclease; Acid Ribonuclease

Substance	CAS Registry & name	Categories	Source	Drugs*
virion host shutoff protein, Simplexvirus [ UL41 protein, simplexvirus,VHS protein, Simplexvirus ] causes host mRNA destabilization in herpes simplex virus; a product of UL41 gene; see also separate records for HSV-1 UL41 and HSV-2 UL41; partial amino acid sequence given in first source	118367-50-3	Ribonucleases Viral Proteins Pharma Action Anti-HIV Agents	Nucleic Acids Res 1991;10(16):4459

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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virion host shutoff protein, Simplexvirus