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icatibant

under Bradykinin
More information in Books or onNLM PubMed
More on Bradykinin Definition: A nonapeptide messenger that is enzymatically produced from KALLIDIN in the blood where it is a potent but short-lived agent of arteriolar dilation and increased capillary permeability. Bradykinin is also released from MAST CELLS during asthma attacks, from gut walls as a gastrointestinal vasodilator, from damaged tissues as a pain signal, and may be a neurotransmitter.      Other names Arg Pro Pro Gly Phe Ser Pro Phe Arg; Bradykinin, (9-D-Arg)-Isomer; Bradykinin, (8-D-Phe)-Isomer; Bradykinin, (7-D-Pro)-Isomer; Bradykinin, (6-D-Ser)-Isomer; Bradykinin, (5-D-Phe-8-D-Phe)-Isomer; Bradykinin, (5-D-Phe)-Isomer; Bradykinin, (3-D-Pro-7-D-Pro)-Isomer; Bradykinin, (3-D-Pro)-Isomer; Bradykinin, (2-D-Pro-7-D-Pro)-Isomer; Bradykinin, (2-D-Pro-3-D-Pro-7-D-Pro)-Isomer; Bradykinin, (2-D-Pro)-Isomer; Bradykinin, (1-D-Arg)-Isomer; Bradykinin Triacetate; Bradykinin Hydrochloride; Bradykinin Diacetate; Bradykinin Acetate, (9-D-Arg)-Isomer; Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg
SubstanceCAS Registry & nameCategoriesSourceDrugs*
icatibant [ D-Arg(Hyp(3)-Thi(5)-D-Tic(7)-Oic(8))BK,HOE 140,HOE-140,HOE140,Hoechst 140,Hoechst-140,JE 049,JE-049,JE049 compound,WIN 65365,WIN-65365,icatibant acetate ]
  an antiasthmatic agent; a potent bradykinin (B2) receptor antagonist; WIN 65365 is an L-Tic(7) stereoisomer, exhibits 2000-fold lower binding affinity than HOE-140 to the bradykinin receptor
130308-48-4   Bradykinin/*analogs & derivatives Receptors, Bradykinin/antagonists & inhibitors
Pharma Action Adrenergic beta-Antagonists; Anti-Inflammatory Agents, Non-Steroidal
Eur J Pharmacol 1990;182(2):395 FIRAZYR

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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