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15-hydroperoxy-5,8,11,13-eicosatetraenoic acid

under Lipid Peroxides
More information in Books or onNLM PubMed
More on Lipid Peroxides Definition: Peroxides produced in the presence of a free radical by the oxidation of unsaturated fatty acids in the cell in the presence of molecular oxygen. The formation of lipid peroxides results in the destruction of the original lipid leading to the loss of integrity of the membranes. They therefore cause a variety of toxic effects in vivo and their formation is considered a pathological process in biological systems. Their formation can be inhibited by antioxidants, such as vitamin E, structural separation or low oxygen tension.      Other names Peroxides, Lipid; Hydroperoxides, Fatty Acid; Hydroperoxide, Lipid; Acid Hydroperoxides, Fatty; Lipoperoxides; Lipid Hydroperoxide; Fatty Acid Hydroperoxides
SubstanceCAS Registry & nameCategoriesSourceDrugs*
15-hydroperoxy-5,8,11,13-eicosatetraenoic acid [ 14,15-epoxyarachidonic acid,15-HPAA,15-HPEA,15-HPETE,15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (E,Z,Z,Z)-isomer,15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (S)-(E,Z,Z,Z)-isomer,15-hydroperoxy-5,8,11,14-eicosatetraenoic acid,15-hydroperoxy-5,8,11,13-eicosatetraenoic acid, (Z,Z,Z,Z)-isomer,15-hydroperoxyarachidonic acid,arachidonic acid 15-hydroperoxide ]
  RN given refers to cpd without isomeric designation; (S-(E,Z,Z,Z))-isomer caused dose-dependent constriction of cat coronary arteries; structure in first source 		67675-14-3 5,8,11,13-eicosatetraenoic acid, 15-hydroperoxy  *Lipid Peroxides *Leukotrienes
Pharma Action Vasoconstrictor Agents; Lipoxygenase Inhibitors 		Adv Prostaglandin Thromboxane Res 1980;6:149; Adv Prostaglandin Thromboxane Res 1:139;1976; Arch Int Pharmacodyn 1979;242(2):285; Arch Int Pharmacodyn 220:297;1976; Experientia 30(2):172;1974; Nature 273(5665):765;1978; Nippon Ronen Igakkai Zasshi 1980;17(1):70; Prostaglandins 1979;18(6):909

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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