Definition: A histamine congener, it competitively inhibits HISTAMINE binding to HISTAMINE H2 RECEPTORS. Cimetidine has a range of pharmacological actions. It inhibits GASTRIC ACID secretion, as well as PEPSIN and GASTRINS output. It also blocks the activity of CYTOCHROME P-450 which might explain proposals for use in NEOADJUVANT THERAPY.
tiotidine [ 2-guanidino-4-(2-(2-cyano-3-methylguanidino)ethylthiomethyl)thiazole,ICI 125,211,tiotidine monofumarate,tiotidine monohydrochloride,tiotidine monomaleate,tiotidine monotartrate, ((R,R)-(+))-isomer ] UD gives slightly different structure for this cpd; RN given refers to parent cpd; structure in first source