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homoharringtonine

under Harringtonines
More information in Books or onNLM PubMed
More on Harringtonines Definition: Tetracyclic spiro-BENZAZEPINES isolated from the seeds of CEPHALOTAXUS. They are esters of the alkaloid cephalotaxine and may be effective as antineoplastic agents.      Other names Cephalotaxus Alkaloids; Cephalotaxine Alkaloids; Alkaloids, Cephalotaxus; Alkaloids, Cephalotaxine
SubstanceCAS Registry & nameCategoriesSourceDrugs*
homoharringtonine [ Ceflatonin,homoharringtonine, 3H-labeled, (3(R))-isomer,omacetaxine mepesuccinate ]
  alkaloid from Cephalotaxus harringtonia; RN given refers to (3(R))-isomer; FDA approved orphan drug status for Ceflatonin in the treatment of chronic myeloid leukemia due to being an inducer of apopto 		26833-87-4   *Harringtonines Leukemia, Myelogenous, Chronic, BCR-ABL Positive Apoptosis
Pharma Action Antineoplastic Agents, Phytogenic; Angiogenesis Inhibitors 		Chin Med J (Eng)92(3):175;1979; J Pharm Sci 61(8):1227;1972

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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