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Complement Pathway, Mannose-Binding Lectin

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Definition: Complement activation triggered by the interaction of microbial POLYSACCHARIDES with serum MANNOSE-BINDING LECTIN resulting in the activation of MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES. As in the classical pathway, MASPs cleave COMPLEMENT C4 and COMPLEMENT C2 to form C3 CONVERTASE (C4B2A) and the subsequent C5 CONVERTASE (C4B2A3B) leading to cleavage of COMPLEMENT C5 and assembly of COMPLEMENT MEMBRANE ATTACK COMPLEX.     
See Also Mannose-Binding Lectin 		Other names Pathways, Mannan-Binding Lectin (Complement Activa; Pathways, Lectin-Complement; Pathway, Mannan-Binding Lectin (Complement Activat; Pathway, Lectin-Complement; Mannose Binding Lectin Complement Pathway; Mannan-Binding Lectin Pathways (Complement Activat; Mannan Binding Lectin Pathway (Complement Activati; Mannan Binding Lectin Complement Pathway; Lectin-Complement Pathways; Lectin Pathways, Mannan-Binding (Complement Activa; Lectin Pathway, Mannan-Binding (Complement Activat; Lectin Complement Pathway; Complement Pathway, Mannose Binding Lectin; Mannan-Binding Lectin Pathway (Complement Activati; Mannose-Binding Lectin Complement Pathway; Mannan-Binding Lectin Complement Pathway; Lectin-Complement Pathway

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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