Definition: A mouse substrain that is genetically predisposed to the development of systemic lupus erythematosus-like syndrome, which has been found to be clinically similar to the human disease. It has been determined that this mouse strain carries a mutation in the fas gene. Also, the MRL/lpr is a useful model to study behavioral and cognitive deficits found in autoimmune diseases and the efficacy of immunosuppressive agents.
a strain predisposed to develop of systemic lupus erythematosus; MRL stands for "Murphy-Roths Lymphoma", lpr stands for "LymphoPRoliferative"; NIM when exper animal: no qualif; when IM, qualif permitted; do not forget also to check MICE; in titles & tran
