Definition: A premalignant change arising in the prostatic epithelium, regarded as the most important and most likely precursor of prostatic adenocarcinoma. The neoplasia takes the form of an intra-acinar or ductal proliferation of secretory cells with unequivocal nuclear anaplasia, which corresponds to nuclear grade 2 and 3 invasive prostate cancer.
/blood supply /chem /second /secret /ultrastruct permitted; coord IM with PROSTATIC NEOPLASMS (IM); DF: PROSTATIC INTRAEPITHELIAL NEOPL