Definition: Transforming glycoprotein coded by the fms oncogene from the Susan McDonough strain of feline sarcoma virus (SM-FeSV). The oncogene protein v-fms lacks sequences, which, in the highly homologous proto-oncogene protein c-fms (CSF-1 receptor), normally serve to regulate its tyrosine kinase activity. The missing sequences in v-fms mimic the effect of ligand and lead to constitutive cell growth. The protein gp120(v-fms) is post-translationally modified to generate gp140(v-fms).
IM; coord with specific virus (IM); /drug eff /ultrastruct permitted; DF: note short X refs
Other names v-fms Protein; gp140(v-fms); gp120(v-fms); fms Oncogene Protein gp140; fms Oncogene Protein gp120; v-fms, gp140; v-fms, gp120; v fms Protein; gp140 v fms; gp120 v fms; gp140 v-fms; gp120 v-fms; fms Oncogene Product gp140; fms Oncogene Product gp120
