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Giant Cells

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Definition: Multinucleated masses produced by the fusion of many cells; often associated with viral infections. In AIDS, they are induced when the envelope glycoprotein of the HIV virus binds to the CD4 antigen of uninfected neighboring T4 cells. The resulting syncytium leads to cell death and thus may account for the cytopathic effect of the virus.  any very large cell; A 11 qualif   
Examples Giant Cells, Foreign-Body; Giant Cells, Langhans 		Other names Syncytium; Polykaryocytes; Multinucleated Giant Cells; Giant Cells, Multinucleated; Polykaryocyte; Multinucleated Giant Cell; Giant Cell, Multinucleated; Giant Cell; Cells, Multinucleated Giant; Cells, Giant; Cell, Multinucleated Giant; Cell, Giant; Syncytia

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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