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Protein Engineering

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Definition: Procedures by which protein structure and function are changed or created in vitro by altering existing or synthesizing new structural genes that direct the synthesis of proteins with sought-after properties. Such procedures may include the design of MOLECULAR MODELS of proteins using COMPUTER GRAPHICS or other molecular modeling techniques; site-specific mutagenesis (MUTAGENESIS, SITE-SPECIFIC) of existing genes; and DIRECTED MOLECULAR EVOLUTION techniques to create new genes.     
See Also Directed Molecular Evolution; Mutagenesis, Site-Directed
Examples Amino Acid Substitution; Mutagenesis, Insertional; Mutagenesis, Site-Directed
Other names Genetic Engineering of Proteins; Protein Genetic Engineering; Engineering, Protein Genetic; Engineering, Protein; Proteins, Genetic Engineering; Genetic Engineering, Protein

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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