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Wernicke Encephalopathy

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Definition: An acute neurological disorder characterized by the triad of ophthalmoplegia, ataxia, and disturbances of mental activity or consciousness. Eye movement abnormalities include nystagmus, external rectus palsies, and reduced conjugate gaze. THIAMINE DEFICIENCY and chronic ALCOHOLISM are associated conditions. Pathologic features include periventricular petechial hemorrhages and neuropil breakdown in the diencephalon and brainstem. Chronic thiamine deficiency may lead to KORSAKOFF SYNDROME. (Adams et al., Principles of Neurology, 6th ed, pp1139-42; Davis & Robertson, Textbook of Neuropathology, 2nd ed, pp452-3)  DF: WERNICKE ENCEPH    Other names Encephalopathy, Wernicke; Beriberi, Cerebral; Wernicke Encephalopathies; Gayet Wernicke Encephalopathy; Encephalopathy, Wernickes; Encephalopathy, Gayet Wernicke; Encephalopathies, Wernicke; Cerebral Beriberi; Wernicke's Syndrome; Wernicke's Superior Hemorrhagic Polioencephalitis; Wernicke's Polioencephalitis, Superior Hemorrhagic; Wernicke's Encephalopathy; Wernicke's Disease; Wernicke Syndrome; Wernicke Superior Hemorrhagic Polioencephalitis; Wernicke Polioencephalitis, Superior Hemorrhagic; Wernicke Disease; Gayet-Wernicke Encephalopathy; Encephalopathy, Wernicke's; Encephalopathy, Gayet-Wernicke

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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