Definition: Inoculation of a series of animals or in vitro tissue with an infectious bacterium or virus, as in VIRULENCE studies and the development of vaccines.
restrict to in vivo or in vitro passage of infectious organisms or develop of vaccines: do not use for passage of cultured cells, cell lines, etc.; NIM; coord with organism or vaccine (IM)
Other names Serial Passages; Passages, Serial; Passage, Serial