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Retrograde Degeneration

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Definition: Pathologic changes that occur in the axon and cell body of a neuron proximal to an axonal lesion. The process is characterized by central chromatolysis which features flattening and displacement of the nucleus, loss of Nissl bodies, and cellular edema. Central chromatolysis primarily occurs in lower motor neurons.      Other names Retrograde Degeneration, Transneuronal; Nissl Degeneration; Axon Reaction; Transneuronal Retrograde Degenerations; Transneuronal Retrograde Degeneration; Trans-Synaptic Degenerations; Trans Synaptic Degeneration; Retrograde Degenerations, Transneuronal; Retrograde Degenerations; Reactions, Axonal; Reactions, Axon; Reaction, Axonal; Reaction, Axon; Degenerations, Transneuronal Retrograde; Degenerations, Trans-Synaptic; Degenerations, Retrograde; Degeneration, Transneuronal Retrograde; Degeneration, Trans-Synaptic; Degeneration, Retrograde; Degeneration, Nissl

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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