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Leukomalacia, Periventricular

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Definition: Degeneration of white matter adjacent to the CEREBRAL VENTRICLES following cerebral hypoxia or BRAIN ISCHEMIA in neonates. The condition primarily affects white matter in the perfusion zone between superficial and deep branches of the MIDDLE CEREBRAL ARTERY. Clinical manifestations include VISION DISORDERS; CEREBRAL PALSY; PARAPLEGIA; SEIZURES; and cognitive disorders. (From Adams et al., Principles of Neurology, 6th ed, p1021; Joynt, Clinical Neurology, 1997, Ch4, pp30-1)  periventricular refers to the cerebral ventricles    Other names Periventricular Leukomalacia; Neonatal Cerebral Leukomalacia; Encephalomalacia, Periventricular; Cystic Periventricular Leukomalacia; Periventricular Leukomalacias, Cystic; Periventricular Leukomalacias; Periventricular Leukomalacia, Cystic; Periventricular Leucomalacias; Periventricular Leucomalacia; Periventricular Encephalomalacias; Periventricular Encephalomalacia; Neonatal Cerebral Leukomalacias; Leukomalacias, Periventricular; Leukomalacias, Neonatal Cerebral; Leukomalacias, Cystic Periventricular; Leukomalacia, Neonatal Cerebral; Leukomalacia, Cystic Periventricular; Leucomalacias, Periventricular; Encephalomalacias, Periventricular; Cystic Periventricular Leukomalacias

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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