Immunoglobulin Switch Region (definition)

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ψ ψ	Immunoglobulin Switch Region

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Definition: A site located in the INTRONS at the 5' end of each constant region segment of a immunoglobulin heavy-chain gene where recombination (or rearrangement) occur during IMMUNOGLOBULIN CLASS SWITCHING. Ig switch regions are found on genes encoding all five classes (IMMUNOGLOBULIN ISOTYPES) of IMMUNOGLOBULIN HEAVY CHAINS.

DF: IG SWITCH REGION
See Also Immunoglobulin Class Switching

Other names Switch Region, Immunoglobulin; Switch Sequences, Ig; Switch Sequence, Ig; Switch Regions, Immunoglobulin; Sequences, Ig Switch; Sequence, Ig Switch; Regions, Immunoglobulin Switch; Region, Immunoglobulin Switch; Immunoglobulin Switch Regions; Ig Switch Sequence; Ig Switch Sequences; Heavy-Chain Mu Switch Region

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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