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Guanosine Pentaphosphate

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Definition: Guanosine 5'-triphosphate 2'(3')-diphosphate. A guanine nucleotide containing five phosphate groups. Three phosphate groups are esterified to the sugar moiety in the 5' position and the other two in the 2' or 3' position. This nucleotide serves as a messenger to turn off the synthesis of ribosomal RNA when amino acids are not available for protein synthesis. Synonym: magic spot II.  /biosyn /physiol permitted; DF: PPPGPP    Other names Pentaphosphate, Guanosine; Guanosine 3' Diphosphate 5' Triphosphate; 5'-Triphosphate, Guanosine 3'-Diphosphate; 3'-Diphosphate 5'-Triphosphate, Guanosine; Guanosine 3'-Diphosphate 5'-Triphosphate

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012
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