Definition: Progressive diminution of the susceptibility of a human or animal to the effects of a drug, resulting from its continued administration. It should be differentiated from DRUG RESISTANCE wherein an organism, disease, or tissue fails to respond to the intended effectiveness of a chemical or drug. It should also be differentiated from MAXIMUM TOLERATED DOSE and NO-OBSERVED-ADVERSE-EFFECT LEVEL.
differentiate from DRUG RESISTANCE; not for tolerability (
ExamplesTachyphylaxis
Other names Tolerances, Drug; Tolerance, Drug; Drug Tolerances
