Definition: A potassium sparing diuretic that acts by antagonism of aldosterone in the distal renal tubules. It is used mainly in the treatment of refractory edema in patients with congestive heart failure, nephrotic syndrome, or hepatic cirrhosis. Its effects on the endocrine system are utilized in the treatments of hirsutism and acne but they can lead to adverse effects. (From Martindale, The Extra Pharmacopoeia, 30th ed, p827)
Other names Spirolactone; von ct, spiro; ct Arzneimittel Brand of Spironolactone; Spirono Isis; SC9420; SC 9420; NovoSpiroton; Novo Spiroton; spiro von ct; duraspiron; ct-Arzneimittel Brand of Spironolactone; betapharm Brand of Spironolactone; W+Śrwag Brand of Spironolactone; Verospirone; Verospiron; Veroshpiron; Spirospare; Spironone; Spirono-Isis; Spirolang
eplerenone [ Inspra,9,11-epoxy-7-(methoxycarbonyl)-3-oxo-17-pregn-4-ene-21,17-carbolactone,Pfizer brand of eplerenone,eplerenon ] a selective aldosterone receptor antagonist; exists in equilibrium with the ring open form SC70303
