Definition: An acidic glycoprotein of MW 23 kDa with internal disulfide bonds. The protein is produced in response to a number of inflammatory mediators by mesenchymal cells present in the hemopoietic environment and at peripheral sites of inflammation. GM-CSF is able to stimulate the production of neutrophilic granulocytes, macrophages, and mixed granulocyte-macrophage colonies from bone marrow cells and can stimulate the formation of eosinophil colonies from fetal liver progenitor cells. GM-CSF can also stimulate some functional activities in mature granulocytes and macrophages.
molgramostim [ Essex brand of molgramostim,Gramal,Leucomax,Made brand of molgramostim,Mielogen,Novartis brand of molgramostim,Probiomed brand of molgramostim,Schering-Plough brand of molgramostim ] amino acid sequence given in first source; recombinant granulocyte macrophage colony-stimulating factor