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jararhagin

under Crotalid Venoms
More information in Books or onNLM PubMed
More on Crotalid Venoms Definition: Venoms from snakes of the subfamily Crotalinae or pit vipers, found mostly in the Americas. They include the rattlesnake, cottonmouth, fer-de-lance, bushmaster, and American copperhead. Their venoms contain nontoxic proteins, cardio-, hemo-, cyto-, and neurotoxins, and many enzymes, especially phospholipases A. Many of the toxins have been characterized.  from pit vipers (rattlesnake, cottonmouth, etc.); /antag permitted but consider also ANTIVENINS; /enzymology permitted; TN 241: common & scientific names of various crotalids    Other names Rattlesnake Venoms; Pit Viper Venoms; Viper Venom, Pit; Venoms, Rattlesnake; Venoms, Pit Viper; Venoms, Crotalid; Venom, Rattlesnake; Venom, Pit Viper; Venom, Crotaline Snake; Venom, Crotalid; Snake Venom, Crotaline; Rattlesnake Venom; Pit Viper Venom; Crotamin; Crotalotoxin; Crotaline Snake Venom; Crotalin; Crotalid Venom; Crotactin
SubstanceCAS Registry & nameCategoriesSourceDrugs*
jararhagin [ HF2 -proteinase,jaracetin ]
  high MW hemorrhagic metalloprotease from Bothrops jararaca venom; 421-amino acid residue; contains disintegrin family with the Arg-Gly-Asp sequence replaced by Glu-Cys-Asp; jaracetin is an alternative
EC 3.4.24.-   *Crotalid Venoms *Metalloendopeptidases
Pharma Action Platelet Aggregation Inhibitors
J Biol Chem 1992 Nov 15;267(32):22869-76

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Sources: NLM Medical Subject Headings, NIH UMLS, Drugs@FDA, FDA AERS original data copyright United States Government. No endorsement implied. Last modified 6/6/2012

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